Your Name:  William Melia

Theme:  Myelodysplastic

 

OPTION LIST

 

A

Chronic myelomonocytic leukaemia (CMML)

I

 

B

Myelodysplastic syndrome associated with isolated del(5q)

J

 

C

Refractory anaemia (RA)

 

K

 

D

Refractory anaemia with excess blasts (RAEB)

L

 

E

Refractory anaemia with excess blasts in transformation (RAEB-t)

M

 

F

Refractory anaemia with ringed sideroblasts (RARS)

N

 

G

 

 

O

 

H

 

 

P

 

 

Sitting in haematology clinic late on a hot Friday evening you are about to see 5 anaemic patients.  Match the most likely diagnosis from the list above to the lab findings detailed below. Each option may be used once, more than once or not at all.

 

1. Peripheral blood:  Macrocytic anaemia, no blasts

    Bone Marrow:       Erythroid dysplasia, 2% blasts, 16% ringed sideroblasts, no Auer rods

 

2. Peripheral blood:  Macrocytic anaemia with pancytopenia, 4% blasts

    Bone Marrow:       Multilineage dysplasia, 13% blasts, no Auer rods

 

3. Peripheral blood:  Macrocytic anaemia, no blasts

    Bone Marrow:       Erythroid dysplasia, 3% blasts, 12% ringed sideroblasts, no Auer rods

 

4. Peripheral blood:  Macrocytic anaemia with monocytopenia, 4% blasts

    Bone Marrow:       Multilineage dysplasia, 19% blasts, no Auer rods

 

5. Peripheral blood:  Macrocytic anaemia with pancytopenia, 8% blasts

    Bone Marrow:       Multilineage dysplasia, 23% blasts, Auer rods present

 

ANSWERS

1.          F

2.          D

3.          C

4.          A

5.          E